CN 41-1243/TG ISSN 1006-852X
Volume 44 Issue 3
Jun.  2024
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HUANG Jieyu, ZENG Zhaowei, WANG Chengyong, YUAN Zhishan. Fabrication and application of double-layer nanopore[J]. Diamond & Abrasives Engineering, 2024, 44(3): 407-414. doi: 10.13394/j.cnki.jgszz.2023.0105
Citation: HUANG Jieyu, ZENG Zhaowei, WANG Chengyong, YUAN Zhishan. Fabrication and application of double-layer nanopore[J]. Diamond & Abrasives Engineering, 2024, 44(3): 407-414. doi: 10.13394/j.cnki.jgszz.2023.0105

Fabrication and application of double-layer nanopore

doi: 10.13394/j.cnki.jgszz.2023.0105
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  • Received Date: 2023-05-08
  • Accepted Date: 2023-06-30
  • Rev Recd Date: 2023-05-27
  • Available Online: 2024-06-28
  • Solid-state nanopores have become the most promising single-molecule sequencing tools due to their adjustable pore size, stable physical and chemical properties, strong adaptability to extreme environments, and high integration. In the area of solid-state nanopores research, improving the detection accuracy of single molecules has always been the core concern of researchers. In recent years, the double-layer nanopores has attracted wide attention. Compared with traditional single-layer nanopore, the "pore-cavity-pore" structure of double-layer nanopores provides two molecular recognition sites and nanoconfined space. The two molecular recognition sites provided by the two nanopores can obtain two target signals in a single translocation event, which not only enrich the detection information but also provide the most direct comparison information source for signal analysis. In addition, the "cavity" in the double-layer nanopores can be used as a single-molecule chemical reactor. Therefore, the appearance of double-layer nanopores broadens the application range of nanopore sensors and has an important application prospect in single molecule detection. In this paper, the development history of nanopores is summarized, and the fabrication methods of double-layer nanopores and their applications in the field of single-molecule detection are emphatically introduced.

     

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